|
KMID : 1123920190330020123
|
|
Korean Journal of Oriental Physiology and Pathology
2019 Volume.33 No. 2 p.123 ~ p.130
|
|
|
Study on Efficacy and Safety of High Dose MOK Pharmacopuncture in Hypothyroidism-induced Rats with Propylthiouracil
|
|
Hwang Ji-Hye
Im Wu-Hyun
Jung Chul
Jung Hyo-Won
|
|
|
Abstract
|
|
|
|
In this study, we investigated the effects of MOK pharmacopuncture at high-doses which are increased 10 to 100-fold in clinics, on propylthiouracil (PTU)-induced hypothyroidism in rats and the safety. We measured the changes of body weight, food and water intake, body temperature, the serum levels of thyroid hormones (TSH, T3, and T4), AST and ALT, glucose, lipid metabolites (total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride) and observed histopathological changes of thyroid tissues by H&E staining. We also analyzed the peaks of constituents of MOK using HPLC. In the results, the treatment of MOK pharmacopuncture at high-dose (30 mg/kg) in hypothyroidism-induced rats for 2 weeks was shown the improvement effects on the decrease of body weight, food intake, and body temperature, The MOK pharmacopunture at high dose regulated the imbalance of thyroid hormones, glucose, and lipid metabolites and also inhibited the structural damages of thyroid tissues. In liver damage, the MOK pharmacopuncture at high dose reduced the increase of AST and ALT levels in hypothyroid rats. We identified the MOK constituents in HPLC analysis. In conclusion, the treatment of MOK pharmacopuncture at high dose has a therapeutic effect on hypothyroidism without liver toxicity, suggesting that the MOK pharmacopuncture be usefully applicable to treat with hypothyroidism in clinics.
|
|
|
KEYWORD
|
|
|
Hypothyroidism, MOK pharmacopuncture, Propylthiouracil (PTU), High-dose
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|